Enterohaemorrhagic and enteropathogenic Escherichia coli use a different Tir-based mechanism for pedestal formation
نویسندگان
چکیده
منابع مشابه
A comparison of enteropathogenic and enterohaemorrhagic Escherichia coli pathogenesis.
This review covers enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) infections, focusing on differences in their virulence factors and regulation. While Shiga-toxin expression from integrated bacteriophages sets EHEC apart from EPEC, EHEC infections often originate from asymptomatic carriage in ruminants whereas human EPEC are considered to be overt pathogens and m...
متن کاملTir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3).
Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detec...
متن کاملEspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis
A key strategy in microbial pathogenesis is the subversion of the first line of cellular immune defences presented by professional phagocytes. Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) remain extracellular while colonizing the gut mucosa by attaching and effacing mechanism. EPEC use the type three secretion system effector protein EspF to prevent thei...
متن کاملRole for CD2AP and other endocytosis-associated proteins in enteropathogenic Escherichia coli pedestal formation.
Enteropathogenic Escherichia coli (EPEC) strains are extracellular pathogens that generate actin-rich structures (pedestals) beneath the adherent bacteria as part of their virulence strategy. Pedestals are hallmarks of EPEC infections, and their efficient formation in vitro routinely requires phosphorylation of the EPEC effector protein Tir at tyrosine 474 (Y474). This phosphorylation results i...
متن کاملUnraveling the role of host endocytic proteins in pedestal formation during enteropathogenic Escherichia coli infection.
Charles Darkoh1,2 and Herbert L. DuPont1,2,3,4,5 1Graduate School of Biomedical Sciences, Molecular Pathology Program, The University of Texas; 2The University of Texas School of Public Health, Center for Infectious Diseases; 3Department of Internal Medicine, The University of Texas Medical School; 4Internal Medicine Service, St. Luke's Episcopal Hospital; and 5Department of Medicine, Baylor Co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2001
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.2001.02617.x