منابع مشابه
Divergent in vivo activity of non‐serotonergic and serotonergic VGluT3–neurones in the median raphe region
KEY POINTS The median raphe is a key subcortical modulatory centre involved in several brain functions, such as regulation of the sleep-wake cycle, emotions and memory storage. A large proportion of median raphe neurones are glutamatergic and implement a radically different mode of communication compared to serotonergic cells, although their in vivo activity is unknown. We provide the first des...
متن کاملTargets of enteric motor neurones: smooth muscle cells.
The cellular targets of enteric motor neurones are gastrointestinal smooth muscle cells, interstitial cells of Cajal (ICC), motor neurones themselves, neuroendocrine cells, mucosal secretory and absorptive cells, secretory glands, blood vessels, and immune cells. The eVects of motor neurones on smooth muscles, particularly the circular muscle cells and ICCs, are precise in timing whereas their ...
متن کاملMonorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones.
In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol-/- embryos, we show that floorplate is induced in the absence of Foxa2 function but fails to further differentiate. In mol-/- mutants, expression of Fo...
متن کاملMidline serotonergic neurones contribute to widespread synchronized activity in embryonic mouse hindbrain.
Spontaneous, synchronous activity occurs in motor neurones of the embryonic mouse hindbrain at the stage when rhombomeric segmentation disappears (embryonic day 11.5). The mechanisms generating and synchronizing the activity, however, and the extent to which it is widespread in the hindbrain, are unknown. We show here that spontaneous activity is initiated in the midline of the hindbrain, and p...
متن کاملClostridium diYcile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig
Background and aims—Evidence suggests that the intestinal actions of Clostridium difficile toxin A—stimulation of secretion and motility, and an acute inflammatory response—have a neurally mediated component. Methods—Direct intracellular electrophysiological recording of electrical and synaptic behaviour in enteric neurones was performed in the submucous plexus of guinea pig small intestine dur...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2009
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2008.167676