Entamoeba histolytica. Phagocytosis as a virulence factor.
نویسندگان
چکیده
منابع مشابه
Entamoeba histolytica. Phagocytosis as a virulence factor
In this paper, we attempted to define the role of phagocytosis in the virulence of Entamoeba histolytica. We have isolated, from a highly phagocytic and virulent strain, a clone deficient in phagocytosis. Trophozoites of wild-type strain HM1:IMSS were fed with Escherichia coli strain CR34-Thy- grown on 5-bromo,2'-deoxyuridine. The trophozoites that had incorporated the base analog through phago...
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The unicellular parasite, Entamoeba histolytica, is exposed to numerous adverse conditions, such as nutrient deprivation, during its life cycle stages in the human host. In the present study, we examined whether the parasite virulence could be influenced by glucose starvation (GS). The migratory behaviour of the parasite and its capability to kill mammalian cells and to lyse erythrocytes is str...
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Cysteine proteinases are hypothesized to be important virulence factors of Entamoeba histolytica, the causative agent of amebic dysentery and liver abscesses. The release of a histolytic cysteine proteinase from E. histolytica correlates with the pathogenicity of both axenic strains and recent clinical isolates as determined by clinical history of invasive disease, zymodeme analysis, and cytopa...
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Amebic erythrophagocytosis is characteristic of invasive amebiasis, and mutants deficient in erythrocyte ingestion are avirulent. We sought to understand the molecular mechanisms underlying erythrocyte phagocytosis by Entamoeba histolytica. Following adherence to amebae, erythrocytes became round and crenulated, and phosphatidylserine (PS) was exposed on their outer membrane leaflets. These cha...
متن کاملTemperature adaptation of Entamoeba histolytica and its effect on virulence.
Cabrera and Porter (1958) found that the maximum culture temperatures for three strains of Entamoeba histolytica (UC, 201 and 202) were 41.0, 41.0, and 41.3”C and the minimum were 32.0, 32.0, and 31.7”C. In the present investigation, by progressive gradual elevation of the culture temperature, these three strains grown in Ringer-Egg-Locke (REL) medium were adapted to 42”C, and one of them to 42...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1983
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.158.5.1511