Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells

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Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells

MOTIVATION In the human genome, 'CpG islands', CG-rich regions located in or near gene promoters, are normally unmethylated. However, in cancer cells, CpG islands frequently gain methylation, resulting in silencing of growth-limiting tumor suppressor genes. To our knowledge, the potential relationship between CpG island hypermethylation, transcription factor (TF) binding in local promoter regio...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2008

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btn256