Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells
نویسندگان
چکیده
منابع مشابه
Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells
MOTIVATION In the human genome, 'CpG islands', CG-rich regions located in or near gene promoters, are normally unmethylated. However, in cancer cells, CpG islands frequently gain methylation, resulting in silencing of growth-limiting tumor suppressor genes. To our knowledge, the potential relationship between CpG island hypermethylation, transcription factor (TF) binding in local promoter regio...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btn256