Enhancing 3-Bromopyruvate Toxicity in Tumor Cells By Inducing Hyperglycemia
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چکیده
منابع مشابه
Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.
3-Bromopyruvate, an alkylating agent and a well-known inhibitor of energy metabolism, has been proposed as a specific anticancer agent. However, the chemopreventive effect of 3-bromopyruvate in lung tumorigenesis has not been tested. In this study, we investigated the chemopreventive activity of 3-bromopyruvate in a mouse lung tumor model. Benzo(a)pyrene was used to induce lung tumors, and 3-br...
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Tumor cells depend on aerobic glycolysis for adenosine triphosphate (ATP) production, which is therefore targeted by therapeutic agents. The compound 3-bromopyruvate (3-BrPA), a strong alkylating agent and hexokinase inhibitor, inhibits tumor cell glycolysis and the production of ATP, causing apoptosis. 3-BrPA induces apoptosis of nasopharyngeal carcinoma (NPC) cell lines HNE1 and CNE-2Z, which...
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[This retracts the article DOI: 10.3892/ol.2014.2779.].
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ژورنال
عنوان ژورنال: Pharmacologia
سال: 2013
ISSN: 2044-4648
DOI: 10.5567/pharmacologia.2013.571.575