Enhancement of delayed rectifier K+ current by P2-purinoceptor stimulation in guinea-pig atrial cells.
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چکیده
منابع مشابه
Sevoflurane inhibition of the slowly activating delayed rectifier K+ current in guinea pig ventricular cells.
Single ventricular cells were enzymatically isolated from guinea pig hearts and the effects of sevoflurane on the delayed rectifier K(+) current were investigated by the patch clamp method. The rapidly (I(Kr)) and slowly activating delayed rectifier K(+) current (I(Ks)) were isolated using chromanol 293B, a selective blocker for I(Ks) or E4031 (N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperid...
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BACKGROUND Angiotensin II (Ang II) has diverse actions on cardiac electrical activity. Little information is available, however, regarding immediate electrophysiological effects of Ang II on cardiac repolarization. METHODS AND RESULTS The present study investigated the immediate effects of Ang II on the slow component of delayed rectifier K+ current (IKs) and action potentials in guinea pig a...
متن کاملExistence of a delayed rectifier K+ current in the membrane of human embryonic stem cel
Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...
متن کاملAlpha 1-adrenoceptor stimulation enhances the delayed rectifier K+ current of guinea pig ventricular cells through the activation of protein kinase C.
The effect of alpha 1-adrenoceptor stimulation on the delayed rectifier K+ current (IK) was examined in isolated guinea pig ventricular cells by use of the patch-clamp method. IK was evoked by a 3-second depolarizing pulse from a holding potential of -30 mV in a Na(+)- and K(+)-free solution containing 3 microM nifedipine. Phenylephrine (30 microM) in the presence of propranolol (1 microM) prod...
متن کاملa 1 - Adrenoceptor Stimulation Enhances the Delayed Rectifier K ' Current of Guinea Pig Ventricular Cells Through the Activation of Protein Kinase C
The effect of cal-adrenoceptor stimulation on the delayed rectifier K' current (IK) was examined in isolated guinea pig ventricular cells by use of the patch-clamp method. 'K was evoked by a 3-second depolarizing pulse from a holding potential of -30 mV in a Na+and K'-free solution containing 3 ,uM nifedipine. Phenylephrine (30 ,uM) in the presence of propranolol (1 ELM) produced an increase in...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1996
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1996.sp021174