Engineering orthogonal substrate specificity in methyltransferases via mutagenesis
نویسندگان
چکیده
منابع مشابه
Probabilistic Approach to Predicting Substrate Specificity of Methyltransferases
We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes. Therefore, our predictive models do not rely on species-specific properties and use mostly sequence-derived data. Maximum Likelihood optimization is used to fine-tune model parameters and the Akaike Information Cr...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2017
ISSN: 2053-2733
DOI: 10.1107/s010876731709674x