Engineering hydrophobically modified chitosan for enhancing the dispersion of respirable microparticles of levofloxacin

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Engineering hydrophobically modified chitosan for enhancing the dispersion of respirable microparticles of levofloxacin.

The potential of amphiphilic chitosan formed by grafting octanoyl chains on the chitosan backbone for pulmonary delivery of levofloxacin has been studied. The success of polymer synthesis was confirmed using FT-IR and NMR, whilst antimicrobial activity was assessed against Pseudomonas aeruginosa. Highly dispersible dry powders for delivery as aerosols were prepared with different amounts of chi...

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ژورنال

عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics

سال: 2014

ISSN: 0939-6411

DOI: 10.1016/j.ejpb.2014.09.005