Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy

Nanomedicine represents a very significant contribution in current cancer treatment; addition to surgical intervention, radiation and chemotherapeutic agents that unfortunately also kill healthy cells, inducing highly deleterious often life-threatening side effects the patient. Of numerous nanoparticles used against cancer, gold had been developed for therapeutic applications. Inter alia, large variety of dendrimers, i.e. soft artificial macromolecules, have turned up as non-viral functional nanocarriers entrapping drugs, imaging agents, targeting molecules. This review will provide insights into design, synthesis, functionalization, development biomedicine engineered functionalized hybrid dendrimer-tangled domain theranostic. Several aspects are highlighted discussed such 1) dendrimer-entrapped gold(0) targeted treatment 2) dendrimer encapsulating (Au DENPs) delivery genes, 3) Au DENPs drug applications, 4) radioactive radiotherapy, 5) dendrimer/dendron-complexed gold(III) technologies take down cells.