Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors
نویسندگان
چکیده
منابع مشابه
Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors.
We have previously demonstrated preclinical in vivo targeting of prostate stem cell antigen (PSCA) using a humanized anti-PSCA 2B3 monoclonal antibody (mAb). However, humanization resulted in 5-fold loss of apparent affinity relative to the parental mAb (1 nM). In this study, diabodies (scFv dimers of 55 kDa) were generated from 2B3 including variants with different linker lengths as well as ba...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2008
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzn055