منابع مشابه
Gene therapy in tissue-engineered blood vessels.
Cardiovascular disease is the leading cause of morbidity and mortality in Western society. More than 1 million arterial bypass procedures are performed annually in the United States, where either autologous veins or synthetic grafts are used to replace arteries in the coronary or peripheral circulation. Tissue engineering of blood vessels from autologous cells has the potential to produce biolo...
متن کاملBlood vessels engineered from human cells.
Human vascular tissue engineering has progressed substantially over the past decade. Issues remain as to the optimum culture scaffold and cell source that should be used for arterial regeneration. In addition, limitations in replicative life span of adult human cells as compared with young animal cells have made human vascular tissue engineering more challenging. Despite these obstacles, severa...
متن کاملAutologous blood vessels engineered from peripheral blood sample.
OBJECTIVE Although many efforts have been made to generate small-diameter (< or =5mm) vascular grafts by means of tissue engineering, improvement in patency and functionality still remains a great challenge. It is our hypothesis that to achieve long-term functionality and patency, not only the complete lining with endothelial cells but also full biocompatibility is essential. DESIGN The aim w...
متن کاملFunctional tissue-engineered blood vessels from bone marrow progenitor cells.
OBJECTIVE Stem cells have significant potential for development of cell-based therapeutics for cardiovascular tissue regeneration. METHODS We developed a novel method for isolating smooth muscle cells (SMC) from ovine bone marrow using a tissue-specific promoter and fluorescence-activated cell sorting. RESULTS As compared to vascular SMC, bone marrow-derived smooth muscle progenitor cells (...
متن کاملElastin biosynthesis: The missing link in tissue-engineered blood vessels.
Nearly 20 years have passed since Weinberg and Bell attempted to make the first tissue-engineered blood vessels. Following this early attempt, vascular tissue engineering has emerged as one of the most promising approaches to fabricate orderly and mechanically competent vascular substitutes. In elastic and muscular arteries, elastin is a critical structural and regulatory matrix protein and pla...
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v130.suppl_1.sci-12.sci-12