Engineered bidirectional promoters enable rapid multi-gene co-expression optimization

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression

Chromatin regulators play an important role in the development of human diseases. In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently. PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei. Mutations of PHF8 are associated with X-linked mental retardation. It usually functions as a transcripti...

متن کامل

Satellite Conceptual Design Multi-Objective Optimization Using Co Framework

This paper focuses upon the development of an efficient method for conceptual design optimization of a satellite. There are many option for a satellite subsystems that could be choice, as acceptable solution to implement of a space system mission. Every option should be assessment based on the different criteria such as cost, mass, reliability and technology contraint (complexity). In this rese...

متن کامل

Programming gene expression with combinatorial promoters

Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and type of binding sites within it. To understand natural genetic circuits and to design promoters for synthetic biology, it is essential to understand the relationship between promoter function and architecture. We constructed a combinatorial libr...

متن کامل

Bidirectional Grammar and Bidirectional Optimization

The human language faculty is a bidirectional system, i.e. it can be used by processes of approximately equal computational complexity to understand and to generate utterances of a language. We assume the general framework of optimality theory and treat the language faculty as a constraint-based system where the very same constraints are uses both in comprehension and in generation. In the simp...

متن کامل

Joint Scheduling and Layout Optimization to Enable Multi-Level Vectorization

We describe a novel loop nest scheduling strategy implemented in the R-Stream compiler : the first scheduling formulation to jointly optimize a trade-off between parallelism, locality, contiguity of array accesses and data layout permutations in a single complete formulation. Our search space contains the maximal amount of vectorization in the program and automatically finds opportunities for a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Communications

سال: 2018

ISSN: 2041-1723

DOI: 10.1038/s41467-018-05915-w