منابع مشابه
Energetic crosstalk between organelles: architectural integration of energy production and utilization.
Cells with high and fluctuating energy demands such as cardiomyocytes need efficient systems to link energy production to energy utilization. This is achieved in part by compartmentalized energy transfer enzymes such as creatine kinase (CK). However, hearts from CK-deficient mice develop normal cardiac function under conditions of moderate workload. We have therefore investigated whether a dire...
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or methoxam(ne, were found to inhibit the release or acetylcholine from Auerbach’s plexus of the ileum. Alpha-receptor blockin 8 drugs prevented this inhibitory action. Removal of sympathetic inhibitory tonic control by reserpinization or by alpha blocking drugs enhanced release of acetylchoi)ne. The results provided neurochemical evidence for the existence presynaptically of alpha-receptors an...
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More than 30% of all lysosomal diseases are mucopolysaccharidoses, disorders affecting the enzymes needed for the stepwise degradation of glycosaminoglycans (mucopolysaccharides). Mucopolysaccharidosis type IIIC (MPS IIIC) is a severe neurologic disease caused by genetic deficiency of heparan sulfate acetyl-CoA: α-glucosaminide N-acetyltransferase (HGSNAT). Through our studies, we have cloned t...
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Peroxisomes are considered to form either by growth and division of existing peroxisomes or de novo from the endoplasmic reticulum. A recent study now demonstrates that mitochondria-derived vesicles are also required for de novo peroxisome biogenesis.
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or are they resolved? Both the ants and the termites cultivate their fungal crops in monocultures. This is remarkable, because there is ample genetic variation of fungal strains across colonies so that horizontal transmission should at least occasionally (in the ants) or regularly (in most termites) establish genetically variable fungus gardens. In the ants, monocultures are actively enforced b...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh1401.093440