Endothelium-derived Relaxing Factors of Small Resistance Arteries in Hypertension
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چکیده
منابع مشابه
Endothelium-derived Relaxing Factors of Small Resistance Arteries in Hypertension
Endothelium-derived relaxing factors (EDRFs), including nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF), play pivotal roles in regulating vascular tone. Reduced EDRFs cause impaired endothelium-dependent vasorelaxation, or endothelial dysfunction. Impaired endothelium-dependent vasorelaxation in response to acetylcholine (ACh) is consistently observ...
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Vascular endothelial cells importantly contribute to the regulation of vascular smooth muscle tone through the production of a variety of vasoactive substances and by direct electric communication through myoendothelial gap junctions.1,2 Moncada et al3 discovered the first endotheliumderived vasoactive substance, prostacyclin, in the mid 1970s and rapidly identified its structure and chemical c...
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ژورنال
عنوان ژورنال: Toxicological Research
سال: 2014
ISSN: 1976-8257
DOI: 10.5487/tr.2014.30.3.141