منابع مشابه
Endothelin-1 in systemic sclerosis
INTRODUCTION Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and organ damage. Endothelin-1 (ET-1) plays a role in skin fibrosis. The aim of this study was survey and comparison of ET-1 level in Systemic Sclerosis (SSc) patients with and without digital ulcer. MATERIAL AND METHODS A cross-sectional analytical study conducted among the 95 ...
متن کاملPlasma endothelin-1 levels in patients with systemic sclerosis: influence of pulmonary or systemic arterial hypertension.
OBJECTIVES To investigate the behaviour of circulating endothelin-1 (ET-1) in patients affected by systemic sclerosis and to elucidate the relationship between systemic and pulmonary plasma peptide and arterial pressure levels. METHODS Plasma ET-1 concentrations were determined in 48 patients affected by systemic sclerosis (41 women, seven men; mean age 47.2 (SD 5.5) years) with or without sy...
متن کاملIncreased endothelin-1 production in fibroblasts derived from patients with systemic sclerosis.
OBJECTIVES To determine whether fibroblasts from patients with systemic sclerosis (SSc) produce excessive amounts of endothelin-1 (ET-1), which is recognised as having vasoconstrictive properties and as having a potent mitogenic effect on fibroblasts. METHODS Dermal fibroblasts were removed from 11 patients with SSc and from five normal controls (NC). The assay of ET-1 protein was measured by...
متن کاملCytokine modulation by endothelin-1 and possible therapeutic implications in systemic sclerosis.
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder characterized by a progressive fibrosis which involves skin and internal organs, caused by microvascular damage. The earliest clinical sign of the disease is Raynauds Phenomenon, a vasospastic response to cold or stress stimuli, followed by the skin and organ involvement over time. This kind of vascular manifestation...
متن کاملHigh frequency skin ultrasonography in systemic sclerosis
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
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ژورنال
عنوان ژورنال: Indian Dermatology Online Journal
سال: 2012
ISSN: 2229-5178
DOI: 10.4103/2229-5178.93484