Endothelial Nitric Oxide Synthase (eNOS) and the Cardiovascular System: in Physiology and in Disease States

Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms gene, uncoupling dimerization, its numerous signaling regulations. activity on cardiac myocytes, vasculature, central nervous system are discussed. effects sympathetic autonomic (SANS) parasympathetic (PANS), both which profoundly influence system, will elaborated. relationship between protein with reflexes such as baroreflex Exercise Pressor Reflex For example, endogenous (NO) shown to mediated by that eNOS-derived endothelial NO is most effective blood pressure oscillations via modulating mechanisms. protective action CVS here because dysfunction enzyme intricately correlated pathogenesis several diseases hypertension, arteriosclerosis, myocardial infarction, stroke. Overall, our current understanding focus modulation, regulation, control normal physiological state