Endothelial Nitric Oxide Gene Knockout Mice
نویسندگان
چکیده
منابع مشابه
Neuronal and endothelial nitric oxide synthase gene knockout mice.
Targeted disruption of the neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) genes has led to knockout mice that lack these isoforms. These animal models have been useful to study the roles of nitric oxide (NO) in physiologic processes. nNOS knockout mice have enlarged stomachs and defects in the inhibitory junction potential involved in gastrointestinal motilit...
متن کاملIncreased salt-sensitivity in endothelial nitric oxide synthase-knockout mice.
BACKGROUND Although impaired nitric oxide production contributes importantly to salt-sensitivity, the role of the endothelial isoform of nitric oxide synthase (eNOS) has received little attention. In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS-/-) and control (eNOS+/+) mice. METHODS Mean arterial pressure (MAP), heart rat...
متن کاملMice Overexpressing Endothelial Nitric Oxide Synthase
Nitric oxide (NO), constitutively produced by endothelial nitric oxide synthase (eNOS), plays a major role in the regulation of blood pressure and vascular tone. We generated transgenic mice overexpressing bovine eNOS in the vascular wall using murine preproendothelin-1 promoter. In transgenic lineages with three to eight transgene copies, bovine eNOS-specific mRNA, protein expression in the pa...
متن کاملConcentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload.
OBJECTIVE Heart failure as a consequence of sustained hemodynamic overload is among the most prevalent diseases in developed countries. The aim of the present study was to investigate the specific role of endothelial nitric oxide synthase (eNOS) in pressure overload-induced left ventricular (LV) hypertrophy. METHODS AND RESULTS Chronic pressure-overload LV hypertrophy was induced by abdominal...
متن کاملRole of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in many countries. The animal models that recapitulate human DN undoubtedly facilitate our understanding of this disease and promote the development of new diagnostic markers and therapeutic interventions. Based on the clinical evidence showing the association of eNOS dysfunction with advanced DN, we and others have creat...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.34.1.24