Endothelial Dysfunction and Low-Grade Inflammation Are Associated With Greater Arterial Stiffness Over a 6-Year Period

Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period.

Endothelial dysfunction and low-grade inflammation are associated with cardiovascular disease. Arterial stiffening plays an important role in cardiovascular disease and, thus, may be a mechanism through which endothelial dysfunction and/or low-grade inflammation lead to cardiovascular disease. We investigated the associations between, on the one hand, biomarkers of endothelial dysfunction (solu...

Arterial Stiffness and Endothelial Dysfunction

Endothelial dysfunction, arterial stiffness, and heart failure.

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results have been negative or neutral. Improvement in surrogate markers has not necessarily translated into better outcomes. To translate breakthroughs with potential therapies into clinical benefit, a better understanding ...

Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period.

BACKGROUND Elastic artery stiffness, a result of arterial aging, is an independent indicator of cardiovascular risk. The aim of the present longitudinal study was to compare the progression of aortic stiffness over a 6-year period in treated hypertensive subjects and normotensive subjects, and to evaluate the determinants of this progression. METHODS AND RESULTS Data for the present analysis ...

Arterial stiffness, endothelial dysfunction and recurrent angina post-chemotherapy.

This case highlights the mechanisms of predicted angina pectoris several days after multi-drug chemotherapeutic regimen for relapsed multiple myeloma. Physicians should recognize that cumulative chemotherapy could exacerbate both arterial stiffness and endothelial dysfunction and result in transiently frequent coronary vasospasm even with clinically permissible doses of vincristine–adriamycin–d...