Endothelial cell mitogen released from HT29 tumour cells grown in monolayer or multicellular spheroid culture
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منابع مشابه
Comparison of radiosensitizing effect of Resveratrol on monolayer and spheroid culture of DU145 prostatic cell line
Background: Radiotherapy is an established therapeutic modality for prostate cancer. Resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. No data is available on the response of cellular spheroid to Reseveratol. In this study we have examined the effect of Resveratol on the radiation response of human p...
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A major limitation with current in vitro technologies for testing anti-cancer therapies at the pre-clinical level is the use of 2D cell culture models which provide a poor reflection of the tumour physiology in vivo. Three dimensional cell culture models, such as the multicellular spheroid, provide instead a more accurate representation. However, existing spheroid-based assessment methods are g...
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Background: Several cell lines when cultured under proper condition can form three dimensional structures called multicellular tumor spheroids. Tumor spheroids are valuable in vitro models for studying physical and biological behavior of real tumors. A number of previous studies using a variety of techniques have shown no relationship between radiosensitivity and DNA strand breaks in monolayer ...
متن کاملcomparison of radiosensitizing effect of resveratrol on monolayer and spheroid culture of du145 prostatic cell line
background: radiotherapy is an established therapeutic modality for prostate cancer. resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. no data is available on the response of cellular spheroid to reseveratol. in this study we have examined the effect of resveratol on the radiation response of human prostate...
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Lack of an in vitro model of metastasis has been a major impediment in understanding the molecular regulation of metastatic processes, and identification of specific therapeutic targets. We have established an in vitro model which displayed the signatures of metastatic phenotype such as migration, invasiveness, chemoresistance and expression of cancer stem-cell markers. This in vitro model was ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1990
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1990.301