Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities
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چکیده
منابع مشابه
Endostatin has ATPase activity, which mediates its antiangiogenic and antitumor activities.
Endostatin is an endogenous angiogenesis inhibitor with broad-spectrum antitumor activities. Although the molecular mechanisms of endostatin have been extensively explored, the intrinsic biochemical characteristics of endostatin are not completely understood. Here, we revealed for the first time that endostatin embedded novel ATPase activity. Moreover, mutagenesis study showed that the ATPase a...
متن کاملEndostatin has novel ATPase activity, which mediates its anti-angiogenic and anti-tumor activities
Endostatin has novel ATPase activity, which mediates its anti-angiogenic and anti-tumor activities Shan Wang, Xin-an Lu, Peng Liu, Yan Fu, Lin Jia, Shunli Zhan, and Yongzhang Luo Authors' Affiliations: The National Engineering Laboratory for Anti-tumor Protein Therapeutics; Beijing Key Laboratory for Protein Therapeutics; and Cancer Biology Laboratory, School of Life Sciences, Tsinghua Universi...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2015
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-14-0836