Endoplasmic Reticulum Stress in Unfolded Protein Response Signalling
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress sensing in the unfolded protein response.
Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded proteins and exit as either folded proteins in transit to their target organelles or as misfolded proteins targeted for degradation. The unfolded protein response (UPR) maintains the protein-folding homeostasis within the ER, ensuring that the protein-folding capacity of the ER meets the load of client protein...
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Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed "ER stress" determining the activation of a finely regulated program defined as unfolded protein response (UPR) and whose primary aim is to restore this organelle's physiological activity. Several physiological and pathological stimuli deregulate normal ER activity causing UPR activation, such as hypoxia...
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ژورنال
عنوان ژورنال: Biochemistry & Analytical Biochemistry
سال: 2015
ISSN: 2161-1009
DOI: 10.4172/2161-1009.1000e157