Endoplasmic Reticulum Stress in Metabolic Disorders
نویسندگان
چکیده
منابع مشابه
Endoplasmic Reticulum (ER) Stress and Endocrine Disorders
The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been rev...
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The endoplasmic reticulum (ER) is the principal organelle responsible for correct protein folding, a step in protein synthesis that is critical for the functional conformation of proteins. ER stress is a primary feature of secretory cells and is involved in the pathogenesis of numerous human diseases, such as certain neurodegenerative and cardiometabolic disorders. The unfolded protein response...
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The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activation of the unfolded protein response (UPR), which intersects with many different inflammatory and stress signaling pathways. These pathways are also critical in chronic metabolic diseases such as obesi...
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Cellular homeostasis is supported by a symphonic balancing act involving protein synthesis, folding, modification, trafficking and degradation. In eukaryotic cells the endoplasmic reticulum (ER) is a specialized organelle that is the central site of synthesis and folding of secretory, membrane and a number of organelletargeted proteins. Correct folding and post-translational modifications of th...
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ژورنال
عنوان ژورنال: Cells
سال: 2018
ISSN: 2073-4409
DOI: 10.3390/cells7060063