Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits
نویسندگان
چکیده
منابع مشابه
Endomysial antibody in the diagnosis and management of coeliac disease.
This review determines the significance, usefulness, and application of the endomysial antibody test for coeliac disease in clinical practice.
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The sensitivities and specificities of the IgA and IgG antigliadin antibody and the IgA antireticulin antibody have been compared with the recently described endomysial antibody directed against the basement membrane of smooth muscle in monkey oesophagus. One hundred and seventeen patients with adult coeliac disease (21 untreated), 84 patients with inflammatory bowel disease, systemic lupus ery...
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Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. Aims: To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. Patients:...
متن کاملCeliac disease: are endomysial antibody test results being used appropriately?
BACKGROUND The aim of this study was to retrospectively examine how positive IgA-endomysial antibody (EMA) test results for celiac disease were being interpreted and acted on by physicians in the Calgary Health Region. METHODS We reviewed consecutive EMA test results, with or without a serum IgA, obtained during a 17-month period. Seropositive tests were cross-referenced to the surgical datab...
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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level and play a key role in the pathogenesis of autoimmune and gastrointestinal diseases. Previous studies have revealed that miRNAs are dysregulated in intestinal biopsies of patients affected by coeliac disease (CD). Combined bioinformatics analyses of miRNA expression profiles and mRNA tar...
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ژورنال
عنوان ژورنال: Gut
سال: 2006
ISSN: 0017-5749
DOI: 10.1136/gut.2005.071514