Endometriosis: Etiology, pathobiology, and therapeutic prospects
نویسندگان
چکیده
منابع مشابه
The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects
In addition to estrogen dependence, endometriosis is characterized by chronic pelvic inflammation. The impact of the chronic pelvic inflammatory state on other organ systems and women's health is unclear. Endometriosis associated chronic inflammation and potential adverse health effects across the lifespan render it imperative for renewed research vigor into the identification of novel biomarke...
متن کاملEtiology of schizophrenia and therapeutic options.
Schizophrenia (SCH) is a major psychiatric disease. The underlying psychopathological mechanisms are not thoroughly understood. Recent working hypotheses on the etiology of SCH discuss numerous molecular mechanisms; those hypotheses require an extensive multidisciplinary research, the results of which would either confirm or discard them. One of the hypotheses discusses the disturbance of membr...
متن کاملBiology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.
Cytoplasmic TDP-43 mislocalization and aggregation is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is an RNA-binding protein (RBP) with a prion-like domain (PrLD) that promotes TDP-43 misfolding. PrLDs possess compositional similarity to canonical prion domains of various yeast proteins, including Sup35. Strikingly, disease-causing TDP-4...
متن کاملSarcoglycanopathies: molecular pathogenesis and therapeutic prospects
Sarcoglycanopathies are a group of autosomal recessive muscle-wasting disorders caused by genetic defects in one of four cell membrane glycoproteins, alpha-, beta-, gamma- or delta-sarcoglycan. These four sarcoglycans form a subcomplex that is closely linked to the major dystrophin-associated protein complex, which is essential for membrane integrity during muscle contraction and provides a sca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2021
ISSN: 0092-8674
DOI: 10.1016/j.cell.2021.04.041