Endometrial Fluid Biomarkers And Their Potential As Predictors Of Successful Embryo Implantation

نویسندگان

چکیده

Background: Embryo implantation is a complex biological process which requires synchronized dialogue between the receptive endometrium and blastocyst. The endometrium, however, only to embryo for very short period. Recurrent failure (RIF) major challenge in assisted reproductive techniques mainly due impaired receptivity, but there still need reliable valid clinical test assess endometrial receptiveness, especially at transfer time. aim of this review investigate what currently known about contribution fluid (EF) receptivity by identifying its potential biomarkers. Methods: This study involved an extensive search electronic databases PubMed Cochrane, covering period from 2011 2022. A combination Medical Subject Headings with terms 'endometrial fluid' ‘embryo implantation’ was used. Results: Several different proteins presented cavity have been described most consistent as biomarkers were Proprotein Convertase 6 (PC6), Vascular Endothelial Growth Factor (VEGF), PIGF (Placental growth factor), β3 integrin, Colony Stimulating Factor-3 (CSF-3), Leukaemia inhibitory factor (LIF), glycodelin extracellular vesicles (EVs). Conclusions: Strong indicators support use uterine collection non-invasive tool assessment. Therefore, it could improve outcomes techniques.

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ژورنال

عنوان ژورنال: Biomedicine

سال: 2023

ISSN: ['2211-8020', '2211-8039']

DOI: https://doi.org/10.37796/2211-8039.1413