Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen
نویسندگان
چکیده
منابع مشابه
Combined oral contraceptives in the treatment of polycystic ovary syndrome.
Combined oral contraceptives (COC) are the most often used treatment modality for polycystic ovary syndrome (PCOS). Undisputedly, COC suppress androgen production, thus ameliorating skin androgenic symptoms and improving menstrual dysfunction. On the other hand, there are still many unresolved issues concerning their metabolic effects. COC could decrease insulin sensitivity and deteriorate gluc...
متن کاملBariatric Surgery, Polycystic Ovary Syndrome, and Infertility
Background. Polycystic ovary syndrome (PCOS) is the commonest cause of female infertility. Visceral obesity and insulin resistance are key pathophysiological mechanisms behind PCOS. Women suffering from this syndrome and infertility often seek bariatric surgery hoping that they would be able to conceive postoperatively. Objective. At present, there is no consensus on the role of bariatric surge...
متن کاملPolycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review
BACKGROUND Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer. METHODS We performed a comprehensive review of the literature using numerous search terms for all studies examining the associations be...
متن کاملPolycystic ovary syndrome and risk of endometrial cancer: a mini-review.
The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism and polycystic ovaries. Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone d...
متن کاملInvestigating the Mechanisms of Endometrial Cancer Risk in Polycystic Ovary Syndrome: Can UK Biobank Help?
Endometrial cancer (EC) is the commonest gynaecological cancer affecting women in the United Kingdom accounting for 43% of all gynaecological cancers. The incidence has increased by over to 60% since the late 1970s. There is an urgent need for research studies looking to improve the diagnosis of EC. The commonest form of EC is type I (well differentiated) and the most frequently altered mutatio...
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ژورنال
عنوان ژورنال: Cancers
سال: 2020
ISSN: 2072-6694
DOI: 10.3390/cancers12071766