Endocrine Modulators of Mouse Subcutaneous Adipose Tissue Beige Adipocyte Markers
نویسندگان
چکیده
منابع مشابه
Evaluation of markers of beige adipocytes in white adipose tissue of the mouse
BACKGROUND There is a growing interest in exploiting the induction of beige or "brite" (brown in white) adipocytes (beigeing) to combat obesity and its comorbidities. However, there is some uncertainty regarding the best markers to evaluate the occurrence or magnitude of beigeing in white adipose tissue in the mouse model. METHODS We evaluated the transcript expression of several thermoregula...
متن کاملBioengineering Beige Adipose Tissue Therapeutics
Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue. Transplantation of brown fat in small animal model systems has confirmed the expectation that brown fat expansion could possibly provide a novel therapeutic to combat obesity and related disorders. Expansion and/or stimul...
متن کاملReview Paper: Adipose Tissue, Adipocyte Differentiation, and Variety of Stem Cells in Tissue Engineering and Regeneration
Human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. Adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...
متن کاملSubcutaneous adipose tissue classification
The developments in the technologies based on the use of autologous adipose tissue attracted attention to minor depots as possible sampling areas. Some of those depots have never been studied in detail. The present study was performed on subcutaneous adipose depots sampled in different areas with the aim of explaining their morphology, particularly as far as regards stem niches. The results dem...
متن کاملDifferential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice
BACKGROUND AND AIMS Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. MATERIAL AND METHODS Sixty animals were randomly assigne...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2015
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.29.1_supplement.595.5