Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence
نویسندگان
چکیده
منابع مشابه
Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence.
BACKGROUND Increased global industrial activity has exposed humans to a wide variety of chemical substances some of which, called 'endocrine-disrupting chemicals' (EDCs) or 'endocrine disruptors', can disrupt the endocrine system in the body. The ovarian follicle is a very fragile micro-environment where interactions between hormones, growth factors, the oocyte and its surrounding somatic cells...
متن کاملDevelopmental effects of endocrine-disrupting chemicals in wildlife and humans.
Large numbers and large quantities of endocrine-disrupting chemicals have been released into the environment since World War II. Many of these chemicals can disturb development of the endocrine system and of the organs that respond to endocrine signals in organisms indirectly exposed during prenatal and/or early postnatal life; effects of exposure during development are permanent and irreversib...
متن کاملFollicular fluid markers of oocyte developmental potential.
BACKGROUND Concentrations of certain substances in follicular fluid (FF) are related to fertilization outcome and early post-fertilization development. The study aim was to identify FF markers with which to predict embryo implantation potential. METHODS Concentrations of selected hormones, cytokines and growth factors in individual FF samples obtained during assisted reproduction treatment we...
متن کاملEndocrine disrupting chemicals
The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...
متن کاملRelationship between growth hormone concentrations in bovine oocytes and follicular fluid and oocyte developmental competence.
In the last few years, several works suggest that Growth Hormone (GH) is involved in follicular development and oocyte maturation. These actions may reflect endocrine roles of pituitary GH and also account for local autocrine or paracrine activities of GH produced in reproductive tissue. This study was aimed to verify whether the developmental competence of bovine female gametes might be relate...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2012
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/der448