Endocrine Cancers: Defying the Paradigms

Changing paradigms in the treatment of endocrine tumors.

Defying bacteriophages

Adaptations by hosts in response to parasitism are generally believed to reduce the susceptibility of the adapted individual. However, recent work on Escherichia coli showed that bacteria can fight deadly phage attacks by committing altruistic suicide upon infection, in order to prevent parasite transmission to nearby relatives. Here, we compare the efficiency of suicidal host defense with indi...

New paradigms in microtubule-mediated endocrine signaling in prostate cancer.

Metastatic prostate cancer has limited therapeutic options and has remained a major clinical challenge. Historically, prostate cancer has been widely recognized as a chemotherapy-resistant disease. However, clinical studies with anti-microtubule agents over the past decade have shown important efficacy in improving survival in patients with advanced disease. The favorable outcomes with microtub...

Defying Unjust Authority: An Exploratory Study

This research explores the psychological factors potentially involved in fostering disobedience to an unjust authority. Our paradigm was modeled after that of the Utrecht Studies on Obedience (Meeus and Raaijmakers European Journal of Social Psychology 16:311-324, 1986) in which participants are ordered to give each of 15 increasingly hostile comments to a participant/victim whenever he fails a...

Death-defying tactics

Death-defying tact ics T here may be 101 ways to kill a cell, but for each there is an escape route. Cells that escape apoptosis, report Anna Colell (Institut d’Investigacions Biomediques de Barcelona, Spain), Jean-Ehrland Ricci (Université de Nice Sophia-Antipolis, France), Douglas Green (St Jude’s Children’s Research Hospital, Memphis, TN), and colleagues, also have a way to escape the back-u...