End of the rainbow indeed

Gene therapy: the end of the rainbow?

The increased understanding of the molecular basis of oral cancer has led to expectations that correction of the genetic defects will lead to improved treatments. Nevertheless, the first clinical trials for gene therapy of oral cancer occurred 20 years ago, and routine treatment is still not available. The major difficulty is that genes are usually delivered by virus vectors whose effects are w...

[At the end of the rainbow....].

The End of the Rainbow ? Color Schemes for Improved Data

Modern computer displays and printers enable the widespread use of color in scientific communication , but the expertise for designing effective graphics has not kept pace with the technology for producing them. Historically, even the most prestigious publications have tolerated high defect rates in figures and illustrations [Cleveland, 1984], and technological advances that make creating and r...

The other end of the rainbow: infrared and skin.

Although infrared radiation (IRR) is ubiquitous in the terrestrial milieu, its effects on human skin have until now been largely ignored. Recent studies suggest an important role for infrared A (IRA) radiation (760-1440 nm) in dermal inflammation, photoaging, and photocarcinogenesis. In this issue, Calles et al. identify and analyze the IRA-induced transcriptome in human dermal fibroblasts. The...

The End of the Rainbow ? Color Schemes for Improved