Encapsulated VEGF121-PLA microparticles promote angiogenesis in human endometrium stromal cells
نویسندگان
چکیده
منابع مشابه
Angiogenesis Following Three-Dimensional Culture of Isolated Human Endometrial Stromal Cells
Background Endometriosis is the presence of endometrial tissue outside of the uterine cavity and is the most common gynecologic disorder in women of reproductive age. We have preliminary evidence that in the presence of a 3-dimensional (3-D) fibrin matrix, human endometrial glands, stroma, and neovascularization can develop in vitro, mimicking the earliest stages of endometriosis. The aim of th...
متن کاملSoluble factors from human endometrium promote angiogenesis and regulate the endothelial cell transcriptome.
BACKGROUND Angiogenesis and vascular remodeling play critical roles in the cyclical growth and regression of endometrium. They also appear to play roles in the pathogenesis of endometriosis. METHODS AND RESULTS Supernatants were collected from cultured endometrium isolated from women with and without endometriosis. These supernatants induced endothelial cell proliferation and angiogenesis in ...
متن کاملAngiogenesis potential of human limbal stromal niche cells.
PURPOSE The perivascular localization of stem cell (SC) niches suggests the presence of a vascular niche. We aimed to determine the angiogenesis potential of limbal niche cells (NCs). METHODS Human limbal NCs were isolated and serially passaged on plastic or coated Matrigel in embryonic SC medium containing BFGF and leukemia inhibitory factor before being reseeded in 3D Matrigel. Expression o...
متن کاملStromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer.
Myofibroblasts, also known as activated fibroblasts, constitute an important niche for tumor development through the promotion of angiogenesis. However, the mechanism of stromal fibroblast activation in tumor tissues has not been fully understood. A gastric cancer mouse model (Gan mice) was recently constructed by simultaneous activation of prostaglandin (PG) E2 and Wnt signaling in the gastric...
متن کاملangiogenesis following three-dimensional culture of isolated human endometrial stromal cells
background: endometriosis is the presence of endometrial tissue outside of the uterine cavity and is the most common gynecologic disorder in women of reproductive age. we have preliminary evidence that in the presence of a 3-dimensional (3-d) fibrin matrix, human endometrial glands, stroma, and neovascularization can develop in vitro, mimicking the earliest stages of endometriosis. the aim of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Genetic Engineering and Biotechnology
سال: 2021
ISSN: 2090-5920
DOI: 10.1186/s43141-021-00118-1