منابع مشابه
Enantioselective organocatalytic reductive amination.
The first enantioselective organocatalytic reductive amination reaction has been accomplished. The development of a new chiral phosphoric acid catalyst has provided a convenient strategy for the enantioselective construction of protected primary amines and provided a highly stereoselective method for the reductive amination of heterocyclic amines. A diverse spectrum of ketone and amine substrat...
متن کاملCatalytic, highly enantioselective, direct amination of enecarbamates.
Amination of enecarbamates with dibenzylazodicarboxylate and oxygenated nucleophiles in the presence of a catalytic amount of chiral phosphoric acid afforded optically active stable precursors of α-hydrazinoimines, which were reduced or oxidized, respectively, to vicinal diamines or α-amino acid precursors with excellent yield and enantioselectivity.
متن کاملEnantioselective Cu-catalyzed decarboxylative propargylic amination of propargyl carbamates
A copper-catalyzed asymmetric propargylic amination with a chiral ketimine P,N,N-ligand that proceeds via decarboxylation of propargyl carbamates has been developed. The reaction can be performed under the mild condition for a broad range of substrates, providing the corresponding propargylic amines in high yields and with up to 97% ee. This reaction represents a new and facile access to optica...
متن کاملAmido-Amino Clay Stabilized Copper Nanoparticles: Antimicrobial Activity and Catalytic Efficacy for Aromatic Amination
Amido-amino functionalized halloysite stabilized copper nanoparticles (aah-CuNPs) were synthesized through one-pot protocol by a wet chemical method using hydrazine as reducing agent. The nanocomposite formed was stable in dry ethanol. The composition and binding nature of the nanocomposite were studied using FT-IR, DRS-UV, EDAX and powder XRD techniques. The morphological features of th...
متن کاملCatalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral amines with the challenging tetrasubstituted carbon stereocentre is a long-standing problem and catalytic asymmetric additions of organometallic reagents to ketimines that would give direct...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2021
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.202004151