Enantioselective Addition of Pyrazoles to Dienes**
نویسندگان
چکیده
We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates range functional groups advances field diene hydrofunctionalization.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202105679