Enantiosective synthesis of a substituted cyclopentanone with all-carbon quaternary stereocenter
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چکیده
منابع مشابه
Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter.
A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand.
متن کاملEnantioselective Synthesis of Bicarbocyclic Structures with an All-Carbon Quaternary Stereocenter Through Sequential Cross Metathesis and Intramolecular Rauhut-Currier Reaction
A new extension of the Birch-Cope sequence is described which allows the efficient enantioselective construction of highly functionalized, fused bicarbocyclic structures with an all-carbon quaternary stereocenter in two steps. The two step sequence includes a cross metathesis between a terminal alkene and a polarized alkene followed by an intramolecular Rauhut-Currier reaction with a trialkylph...
متن کاملEnantioselective metallo-organocatalyzed preparation of cyclopentanes bearing an all-carbon quaternary stereocenter.
Enantioselective metallo-organocatalyzed carbocyclizations of formyl-alkynes have been developed. The cooperation between aminocatalysis and a chiral copper(I) complex granted access to enantio-enriched cyclopentanes through the challenging formation of all-carbon quaternary stereocenters.
متن کاملsingle-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
15 صفحه اولCatalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters Catalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters
SYNTHESIS 2006, No. 3, pp 0369–0396xx.xx.2006 Advanced online publication: 13.01.2006 DOI: 10.1055/s-2006-926302; Art ID: E14205SS © Georg Thieme Verlag Stuttgart · New York Abstract: Catalytic enantioselective construction of all-carbon quaternary stereocenters, i.e. carbon atoms bearing four different carbon substituents, poses a particular challenge in organic synthesis. This review gives a ...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2017
ISSN: 1551-7012
DOI: 10.24820/ark.5550190.p010.173