Emulating native periosteum cell population and subsequent paracrine factor production to promote tissue engineered periosteum-mediated allograft healing
نویسندگان
چکیده
منابع مشابه
The relationship between periosteum and fracture healing.
Fracture healing is a complex process that involves presence of osteoprogenitor cells and growth factors. Therefore, the integrity of the fracture site surrounding tissues including periosteum is necessary in order to provide the resources for bone regeneration. The purpose of this review is to organize and synthesize the relevant information regarding periosteum and fracture repair. Periosteum...
متن کاملPeriosteum Fracture Bone Strength THE MECHANICAL ROLE OF THE PERIOSTEUM ON THE IMPACT RESISTANCE OF BONE
Introduction: The role of periosteum in the blood supply of bones has been investigated by several investigators [5]. Its osteogenic potential, particularly its important role in fracture repair, is also well recognized [1, 3]. However, the biomechanical role of periosteum in the fracture behavior of bones has not been studied in detail. Although the periosteum is expected to be resistant to te...
متن کاملRegeneration of Periosteum in Denuded Bone
Fig. 1. Schematic of one-stage bone-transport procedure (yellow – bone, red – periosteum). A portion of diaphyseal bone is denuded of periosteum, osteotomized, and transported over an intramedullary nail to the site of the 2.54-cm critical-sized defect, where it is docked to the distal femur. The periosteal sheath is left in situ to surround the new defect site, leading to full infilling of the...
متن کاملEffective bone engineering with periosteum-derived cells.
Bone augmentation via tissue engineering has generated significant interest. We hypothesized that periosteum-derived cells could be used in place of bone marrow stromal cells (which are widely used) in bone engineering, but the differences in osteogenic potential between these 2 cell types are unclear. Here, we compared the osteogenic potential of these cells, and investigated the optimal osteo...
متن کاملPeriosteum: A Highly Underrated Tool in Dentistry
The ultimate goal of any dental treatment is the regeneration of lost tissues and alveolar bone. Under the appropriate culture conditions, periosteal cells secrete extracellular matrix and form a membranous structure. The periosteum can be easily harvested from the patient's own oral cavity, where the resulting donor site wound is invisible. Owing to the above reasons, the periosteum offers a r...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2015
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2015.02.064