Empirical Cephalosporin Treatment of Melioidosis

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Empirical cephalosporin treatment of melioidosis.

treated patients, 68.3% of amoxicillin/clavulanic acid–treated paMelioidosis, or infection by Burkholderia pseudomallei, remains tients, and 78.3% of cefotaximeor ceftriaxone-treated patients. a serious cause of mortality and morbidity in northeastern Thailand Among these septicemic patients, the mortality rates were 59.6%, [1]. During the months of the rainy season, B. pseudomallei is the 67.5...

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Melioidosis is a complex bacterial infection, treatment of which combines the urgency of treating rapidly fatal Gram negative septicaemia with the need for eradication of long-term persistent disease in pulmonary, soft tissue, skeletal and other organ systems. Incremental improvements in treatment have been made as a result of multicentre collaboration across the main endemic region of Southeas...

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Treatment and prophylaxis of melioidosis

Melioidosis, infection with Burkholderia pseudomallei, is being recognised with increasing frequency and is probably more common than currently appreciated. Treatment recommendations are based on a series of clinical trials conducted in Thailand over the past 25 years. Treatment is usually divided into two phases: in the first, or acute phase, parenteral drugs are given for ≥10 days with the ai...

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Treatment of pulmonary melioidosis with combination of trimethoprim and sulfamethoxazole.

Treatment with a combination of trimethoprim and sulfamethoxazole proved lifesaving in a patient with pulmonary melioidosis after therapeutic failure occurred with other antibiotics to which the organisms were sensitive in vitro. Antagonistic interaction of drugs occurred when the combination of trimethoprim and sulfamethoxazole was given along with other antibiotics. The combination of trimeth...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 1999

ISSN: 1058-4838,1537-6591

DOI: 10.1086/517787