Empirical antimicrobial therapy for probable v. directed therapy for possible ventilator-associated pneumonia in critically injured patients

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Empirical antimicrobial therapy for probable v. directed therapy for possible ventilator-associated pneumonia in critically injured patients.

BACKGROUND Ventilator-associated pneumonia (VAP) has recently been classified as possible or probable. Although direct attributable mortality has been difficult to prove, delay in instituting appropriate therapy has been reported to increase morbidity and mortality. Recent literature suggests that in possible VAP, instituting directed therapy while awaiting microbiological culture does not prej...

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Empirical Antibiotic Therapy for Ventilator-Associated Pneumonia

Ventilator-associated pneumonia (VAP) is the most common infectious complication in the intensive care unit. It can increase duration of mechanical ventilation, length of stay, costs, and mortality. Improvements in the administration of empirical antibiotic therapy have potential to reduce the complications of VAP. This review will discuss the current data addressing empirical antibiotic therap...

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Empiric antimicrobial therapy for ventilator-associated pneumonia after brain injury.

Issues regarding recommendations on empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) have emerged in specific populations.To develop and validate a score to guide empiric therapy in brain-injured patients with VAP, we prospectively followed a cohort of 379 brain-injured patients in five intensive care units. The score was externally validated in an independent cohort of 2...

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Ventilator Associated Pneumonia by Acinetobacter baumannii And antimicrobial susceptibility pattern

Background: Ventilator Associated Pneumonia (VAP) is one of the serious complications of ventilator support occurring in ICUs. The aim of this study was to determine the susceptibility pattern of Acinetobacter baumannii (A. baumannii) isolated from patients with VAP by two methods: disk diffusion and E. test. Methods: This descriptive-cross sectional study was conducted in the four ICUs of Ras...

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Optimising the duration of antibiotic therapy for ventilator-associated pneumonia

Ventilator-associated pneumonia (VAP) has traditionally been treated with a 14–21day course of antibiotics. However, prolonged antibiotic therapy is associated with the emergence of multidrug-resistant strains, as well as higher toxicity and costs. In a large, randomised, controlled trial in patients with microbiologically confirmed VAP who received appropriate empirical antibiotic therapy, an ...

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ژورنال

عنوان ژورنال: South African Medical Journal

سال: 2016

ISSN: 2078-5135

DOI: 10.7196/samj.2016.v106i2.9870