EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells
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چکیده
منابع مشابه
CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer
Triple negative breast cancers exhibit very aggressive features and poor patient outcomes. These tumors are enriched in cancer stem cells and exhibit resistance to most treatments and chemotherapy. In this study, we found the cyclin-dependent kinase (CDK4) to act as a cancer stem cell regulator and novel prognostic marker in triple negative breast cancers. We found CDK4 to be highly expressed i...
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15 صفحه اولHypoxia regulates stemness of breast cancer MDA-MB-231 cells.
Human breast cancers include cancer stem cell populations as well as non-tumorigenic cancer cells. Breast cancer stem cells possess self-renewal capability and thus are the root cause of recurrence and metastasis of malignant tumors. Hypoxia is a fundamental pathological feature of solid tumor tissues and exerts a wide range of effects on the biological behavior of cancer cells. However, there ...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2020
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-19-0850