Emerging roles of proximal tubular endocytosis in renal fibrosis

Endocytosis is a crucial component of many pathological conditions. The proximal tubules are responsible for reabsorbing the majority filtered water and glucose, as well all proteins through glomerular barrier via endocytosis, indicating an essential role in kidney diseases. Genetic mutations or acquired insults could affect tubule endocytosis processes, by disturbing overstressing endolysosomal system subsequently activating different pathways, orchestrating renal fibrosis. This paper will review recent studies on tubular affected other diseases factors. plays vital development fibrosis, fibrosis also, turn, endocytosis.