منابع مشابه
Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation
Integration of multiple profiling data and construction of functional gene networks may provide additional insights into the molecular mechanisms of complex diseases. Osteoporosis is a worldwide public health problem, but the complex gene-gene interactions, post-transcriptional modifications and regulation of functional networks are still unclear. To gain a comprehensive understanding of osteop...
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Arabidopsis thaliana (Arabidopsis) is ideally suited for studies of natural phenotypic variation. This species has also provided an unparalleled experimental system to explore the mechanistic link between genetic and epigenetic variation, especially with regard to cytosine methylation. Using high-throughput sequencing methods, genotype to epigenotype to phenotype observations can now be extende...
متن کاملHuman DNA methylomes of neurodegenerative diseases show common epigenomic patterns
Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neuro...
متن کاملMining Generalised Emerging Patterns
Emerging Patterns (EPs) are a data mining model that is useful as a means of discovering distinctions inherently present amongst a collection of datasets. However, current EP mining algorithms do not handle attributes whose values are asscociated with taxonomies (is-a hierarchies). Current EP mining techniques are restricted to using only the leaf-level attribute-values in a taxonomy. In this p...
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The discovery of emerging patterns (EPs) is a descriptive data mining task defined for pre-classified data. It aims at detecting patterns which contrast two classes and has been extensively investigated for attribute-value representations. In this work we propose a method, named Mr-EP, which discovers EPs from data scattered in multiple tables of a relational database. Generated EPs can capture...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2011
ISSN: 0168-9525
DOI: 10.1016/j.tig.2011.03.001