Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE
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چکیده
منابع مشابه
Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE
The H-type of atypical bovine spongiform encephalopathy (H-BSE) was serially passaged in bovinized transgenic (TgBoPrP) mice. At the fourth passage, most challenged mice showed a typical H-BSE phenotype with incubation periods of 223 ± 7.8 days. However, a different phenotype of BSE prion with shorter incubation periods of 109 ± 4 days emerged in a minor subset of the inoculated mice. The latte...
متن کاملBovine Spongiform Encephalopathy (BSE)
Detailed tables containing information on countries in which BSE has been reported are provided by the World Organisation for Animal Health (OIE) on its website (BSE specific data – www.oie.int). Apart from the 184 169 cases in cattle that were diagnosed in the UK up to the end of 2011, 20 other European countries also recorded the disease, some such as Portugal, Switzerland and Ireland at high...
متن کاملHuman prion diseases and bovine spongiform encephalopathy (BSE).
Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein. Recent evidence argues that prion protein can...
متن کاملEpidemiological Analysis of Bovine Spongiform Encephalopathy (bse)
Bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, chronic wasting disease (CWD) in cervids, and Creutzfeldt-Jakob disease (CJD) in humans are known as prion diseases or transmissible spongiform encephalopathies (TSE), which cause neurodegenerative disorders. BSE was first reported in the United Kingdom (UK) in 1987, following which over 180,000 cases have been report...
متن کاملBSE--bovine spongiform encephalopathy ('mad cow disease').
About BSE BSE (bovine spongiform encephalopathy) is a progressive neurological disorder of cattle that results from infection by an unusual transmissible agent called a prion. The nature of the transmissible agent is not well understood. Currently, the most accepted theory is that the agent is a modified form of a normal protein known as prion protein. For reasons that are not yet understood, t...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep22753