Emergence of a Highly Pathogenic Avian Influenza Virus from a Low-Pathogenic Progenitor

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Highly Pathogenic Avian Influenza A(H5N1) Virus

Author affiliations: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany (I.A. Asante, S. Bertram, G. Gabriel); Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana (I.A. Asante, W.K. Ampofo); Center for Structural and Cellular Biology in Medicine at the University of Lübeck, Lübeck, Germany (S. Bertram, G. Gabriel); Veterinary S...

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UNLABELLED The novel H7N9 avian influenza virus (AIV) was demonstrated to cause severe human respiratory infections in China. Here, we examined poultry specimens from live bird markets linked to human H7N9 infection in Hangzhou, China. Metagenomic sequencing revealed mixed subtypes (H5, H7, H9, N1, N2, and N9). Subsequently, AIV subtypes H5N9, H7N9, and H9N2 were isolated. Evolutionary analysis...

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The potential role of wild birds as carriers of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 is still a matter of debate. Consecutive or simultaneous infections with different subtypes of influenza viruses of low pathogenicity (LPAIV) are very common in wild duck populations. To better understand the epidemiology and pathogenesis of HPAIV H5N1 infections in natural ecosystems, w...

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Discrimination between Highly Pathogenic and Low Pathogenic H5 Avian Influenza A Viruses

700 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 12, No. 4, April 2006 9. Monath TP, Caldwell JR, Mundt W, Fusco J, Johnson CS, Buller M, et al. ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain): a second-generation smallpox vaccine for biological defense. Int J Infect Dis. 2004;8S2: S31–44. 10. Graham BS, Belshe RB, Clements ML, Dolin R, Corey L, ...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2014

ISSN: 0022-538X

DOI: 10.1128/jvi.03181-13