Elucidation of Isoform-dependent pH Sensitivity of Troponin I by NMR Spectroscopy
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چکیده
منابع مشابه
Elucidation of isoform-dependent pH sensitivity of troponin i by NMR spectroscopy.
Myocardial ischemia is characterized by reduced blood flow to cardiomyocytes, which can lead to acidosis. Acidosis decreases the calcium sensitivity and contractile efficiency of cardiac muscle. By contrast, skeletal and neonatal muscles are much less sensitive to changes in pH. The pH sensitivity of cardiac muscle can be reduced by replacing cardiac troponin I with its skeletal or neonatal cou...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.301499