Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile

CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3.

The affinity of the MHC/peptide/TCR interaction is thought to be one factor determining the differentiation of CD4+ T cells into Th1 or Th2 phenotypes. To study whether CD4+ cells generated under conditions favoring Th1 or Th2 responses select structurally different TCRs, Th1 and Th2 clones and lines were generated from nonobese diabetic and nonobese diabetic H2-E transgenic mice against the pe...

TCR- CDR3 Loop Audition Regulates Positive Selection

Analysis of the TCR alpha and beta chain CDR3 spectratypes in the peripheral blood of patients with Systemic Lupus Erythematosus

Email: Wei Luo [email protected]; Li Ma* [email protected]; Qian Wen [email protected]; XinSheng Yao [email protected]; Na Wang [email protected]; Hong-Yun Zou [email protected]; MingQian Zhou [email protected]; Ying Lin [email protected]; Zhen-Qiang Wu [email protected]; Xiao-Wei He [email protected]; Ju-Fang Wang [email protected]; Xiao-Ning Wang* [email protected] * Corresponding authors

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.

T cell responses to MHC-mismatched transplants can be mediated via direct recognition of allogeneic MHC molecules on the cells of the transplant or via recognition of allogeneic peptides presented on the surface of recipient APCs in recipient MHC molecules - a process known as indirect recognition. As CD4(+)CD25(+) Tregs play an important role in regulating alloresponses, we investigated whethe...

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing.

BACKGROUND/AIMS To ward off a wide variety of pathogens, the human adaptive immune system harbors a vast array of T-cell receptors, collectively referred to as the TCR repertoire. Assessment of the repertoire features of TCR is vital for us to deeper understand of immune behaviour and immune response. METHODS In this study, we used a combination of multiplex-PCR, Illumina sequencing and IMGT ...