Elevation of (Pro)Renin and (Pro)Renin Receptor in Preeclampsia
نویسندگان
چکیده
منابع مشابه
Prorenin and its ancient receptor.
Prorenin, the precursor of renin, has for a long time been considered to be functionally inert, despite high circulating concentrations. Plasma levels of prorenin usually exceed renin levels and are even further increased under pathological conditions, such as in diabetes. First support of a functional significance of prorenin came from studies in transgenic rats, which overexpress a renin gene...
متن کاملThe prorenin receptor: what's in a name.
The discovery of the prorenin receptor, now nearly a decade ago, altered our view of the renin-angiotensin system (RAS).1,2 Binding of prorenin, the inactive precursor of renin, to the prorenin receptor results in full catalytic activity of prorenin through a nonproteolytic mechanism that likely involves a conformational change by which the prosegment moves out of the catalytic cleft, which the...
متن کاملHuman prorenin.
Human prorenin is the enzymatically inactive biosynthetic precursor of renin. Recent interest has focused on the posttranslational sorting and processing of prorenin to renin since markedly increased levels of circulating prorenin have been associated with both physiological and pathological changes. These observations raise the question of whether prorenin processing may be a regulatory event ...
متن کاملPurification of renin and prorenin.
In this issue of the journal, we feature two articles—one by Tadashi Inagami and the other by Pierre Corvol and Joel Menard—relating the story of the purification of renin. These investigators received the 1985 CIBA Award for Hypertension Research for biochemical studies leading to the isolation, amino acid structural and three-dimensional configuration, and the physiochemical and immunochemica...
متن کاملBinding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system.
The rat recombinant renin/prorenin receptor (AB188298 in DDJB), which conjugated with FLAG epitope in its N-terminus, was expressed in a baculovirus expression system. The recombinant receptor, prepared from the cytoplasmic fraction of the insect cells, was identified by Western blotting using anti-FLAG antibody. Prorenin as well as renin bound to the receptor with different binding affinities....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2015
ISSN: 0895-7061,1941-7225
DOI: 10.1093/ajh/hpv019