Elevated Tumor-Associated Antigen Expression Suppresses Variant Peptide Vaccine Responses

Vaccine Responses Expression Suppresses Variant Peptide Elevated Tumor-Associated Antigen

Expression Suppresses Variant Peptide Elevated Tumor-Associated Antigen

Growth Associated with Apoptosis Induction Peptide Vaccine Induces Enhanced Tumor

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

Prostaglandin E2 (PGE2) favors multiple aspects of tumor development and immune evasion. Therefore, microsomal prostaglandin E synthase (mPGES-1/-2), is a potential target for cancer therapy. We explored whether inhibiting mPGES-1 in human and mouse models of breast cancer affects tumor-associated immunity. A new model of breast tumor spheroid killing by human PBMCs was developed. In this model...

Mining the melanosome for tumor vaccine targets: P.polypeptide is a novel tumor-associated antigen.

To identify novel, tumor-specific target antigens for vaccine development, we studied immune responses to P.polypeptide, an M(r) 110,000 integral melanosomal membrane protein associated with the Prader-Willi syndrome. Together with expressed sequence tag (EST) and serial analyses of gene expression (SAGE) library analyses, reverse transcription-PCR and Northern blotting verified that P.polypept...