Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors
نویسندگان
چکیده
منابع مشابه
Elevated plasma adiponectin and leptin levels in sisters with genetically defective insulin receptors.
C irculating levels of adiponectin have been shown to inversely correlate with insulin sensitivity. Interestingly, elevated adiponectin levels have been observed following treatment with thiazolidinediones. It has recently been reported (1) that paradoxical hyperadiponectinemia is observed in patients with mutations, leading to a loss of insulin receptor function. Here, we evaluated circulating...
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The aim of this study is to determine and compare the effect of obesity or insulin deficiency on plasma adiponectin level and peripheral blood leukocyte (PBL) adiponectin receptor 1 and 2 (ADIPOR1 and -R2) expression in dogs. Obese and insulin deficient (ID) dogs demonstrated a significant reduction (60% lower) and significant increase (2x higher) in circulating adiponectin level, respectively,...
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متن کاملPlasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans.
Adiponectin, the most abundant adipose-specific protein, has been found to be negatively associated with degree of adiposity and positively associated with insulin sensitivity in Pima Indians and other populations. Moreover, adiponectin administration to rodents has been shown to increase insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and also increase whole-body insulin ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2006
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2006-0166