Elemene inhibits the growth and promotes apoptosis of bladder cancer cells through PTEN-Akt signaling pathway
نویسندگان
چکیده
Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, involvement phosphatase tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway process.
 Methods: Human cell line SV-HUC-1 human T24 were randomly assigned to blank control group groups. Protein expression levels apoptosis-related factors (Bcl-2, Bax, caspase-3] PTEN, Akt, p-Akt both cells determined using western blot assay.
 Results: In level Bcl-2 was significantly higher than control, while Bax caspase-3 lower corresponding (p < 0.05). The PTEN group, Akt comparable groups.
 Conclusion: Elemene inhibits enhances apoptosis through a mechanism involving up-regulation suppression pAkt.
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2023
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v22i5.6