Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin
نویسندگان
چکیده
منابع مشابه
Photodynamic Inactivation of Endopathogenic Microbiota Using Curcumin- mediated Antimicrobial Photodynamic Therapy
Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems. In this study, a series of experiments investigated the effects of aPDT on cell viability and biofilm degradation ability of endopathogenic mic...
متن کاملPhotodynamic Therapy with Hypericin Improved by Targeting HSP90 Associated Proteins
In this study we have focused on the response of SKBR-3 cells to both single 17-DMAG treatment as well as its combination with photodynamic therapy with hypericin. Low concentrations of 17-DMAG without any effect on survival of SKBR-3 cells significantly reduced metabolic activity, viability and cell number when combined with photodynamic therapy with hypericin. Moreover, IC10 concentation of 1...
متن کاملPolymeric photosensitizer prodrugs for photodynamic therapy.
A targeting strategy based on the selective enzyme-mediated activation of polymeric photosensitizer prodrugs (PPP) within pathological tissue has led to the development of agents with the dual ability to detect and treat cancer. Herein, a detailed study of a simple model system for these prodrugs is described. We prepared "first-generation" PPP by directly tethering the photosensitizer (PS) phe...
متن کاملBenefits of nanoencapsulation for the hypericin-mediated photodetection and photodynamic therapy of ovarian micrometastases
Ovarian cancer is the fourth most frequent cause of cancer-related death in women in the United States. The currently recommended treatment is a combination of surgery followed by chemotherapy. However, ovarian cancer is characterized by the development of peritoneal micrometastases. These latter, hardly detectable by conventional method, are therefore suboptimally treated by standard surgery. ...
متن کاملHypericin in the Dark: Foe or Ally in Photodynamic Therapy?
Photosensitizers (PSs) in photodynamic therapy (PDT) are, in most cases, administered systemically with preferential accumulation in malignant tissues; however, exposure of non-malignant tissues to PS may also be clinically relevant, when PS molecules affect the pro-apoptotic cascade without illumination. Hypericin (Hyp) as PS and its derivatives have long been studied, regarding their photodyn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Photodiagnosis and Photodynamic Therapy
سال: 2013
ISSN: 1572-1000
DOI: 10.1016/j.pdpdt.2013.08.001