Electroporation delivery of DNA vaccines: prospects for success

Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates.

Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development o...

Prospects for new vaccines.

Delivery of DNA vaccines against cancer

DNA vaccines against cancer have shown promising results in animal models. Efficient antigen-specific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. Phase I clinical trials have furthermore demonstrated that repetitive DNA vaccinations in humans are well tolerated, and that tumor antigen-specific immune responses can be i...

Delivery of plasmid DNA by in vivo electroporation Review Article

Loree Heller and M. Lee Lucas Center for Molecular Delivery, University of South Florida, Tampa, FL 33612, Department of Medical Microbiology, University of South Florida, Tampa, FL 33612 __________________________________________________________________________________ * Correspondence : Loree Heller, University of South Florida, Center for Molecular Delivery, MDC16, 12901 Bruce B. Downs Blvd....

Prospects for new vaccines A